Sketch Turner, a "starving artist" and freelance rock musician living in New York City, is working on his newest comic book, named the "Comix Zone." Comix Zone is the story of the New World Empire's attempt to defend Earth from an invasion of alien renegades, with inspiration coming from Sketch's (oddly vivid) dreams and nightmares. One night, while Sketch is working on Comix Zone during a thunderstorm, a lightning bolt strikes a panel of his comic. In this instant, the main villain of Comix Zone - a powerful mutant named Mortus - manages to escape the comic book's pages, desiring to kill Sketch so he can become flesh and blood and take over the real world. Because he does not possess any power in reality, Mortus sends Sketch into the world of his own comic, freely drawing in enemies attempting to kill him.
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